主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

中国司法鉴定 ›› 2010 ›› Issue (6): 36-40.

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青霉素类抗生素分析研究进展及其应用

陈 聪12，严慧2，沈保华2等   

  1. 1.复旦大学 上海医学院 法医系 ，上海200032;
    2.司法部司法鉴定科学技术研究所 上海市法医学重点实验室，上海 200063
  • 收稿日期:2010-09-06 出版日期:2010-11-15 发布日期:2022-07-07
  • 通讯作者: 卓先义，研究员。主要从事毒物分析研究。
  • 作者简介:陈聪（1984-），男，硕士研究生。主要从事毒物分析研究。

A Research on Detection and Application of Penicillin Antibiotics

CHEN Cong2, YA.N Hui2, SHEN Bao-huc, etc.   

  1. 1.Department of Forensic Medicine, Shanghai Medical College, Fudan university, Shanghai 200032,China;
    2.Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science,Ministry of Justice,Shanghai 200063,China
  • Received:2010-09-06 Published:2010-11-15 Online:2022-07-07

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摘要： 青霉素类抗生素具有杀菌活性强、毒副作用小等特点，在临床、动物饲养中应用非常广泛，但使用此类抗生素可能会对某些个体引起过敏反应甚至死亡，同时该类药物的β-内酰胺环不稳定，易受 pH值、温度和β-内酰胺酶的影响而开环，原体进入生物体后极易分解，代谢快，检测时限短，因此寻找稳定性好和检测时限长的代谢产物对青霉素类抗生素的检测显得十分重要。本文就近年来青霉素类抗生素的检测方法、稳定性研究、代谢物检测及其在食品中的残留检测、法医学领域中的应用等内容进行了综述。

关键词: 药物检测, 青霉素类抗生素, 代谢物, 残留

Abstract: As Penicillin antibiotics has strong anti-microbial activities without severe adverse effects, it has been used exten-sively both in clinic and animal breeding practices. However,penicillins may cause allergic reactions, even deaths in some in-dividuals,In addition,β-lactam ring of penicillins is unstable, which is highly sensitive to pH, heat and β-lactam enzymes. Besides, penicillins decompose easily and metabolize fast in human body, which makes the window of detection short. There-fore, it is necessary to find stable metabolites, which have longer detection window. This paper summarizes the current re-searches on determination of penicillin antibiotics, especially emphasizing on the advancements of analysis methods and mebabolites detection, and prospects for applications in food safety and forensic science. 

Key words: drug monitoring, penicillins, metabolite, residue

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