主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

中国司法鉴定 ›› 2023 ›› Issue (6): 40-47.DOI: 10.3969/j.issn.1671-2072.2023.06.006

• 鉴定综述 • 上一篇    下一篇

移液吸头微萃取技术在法医毒物分析中的应用

阳 硕1，2，相佳宏1，李子怡1，2，等   

  1. 1.司法鉴定科学研究院 上海市法医学重点实验室 上海市司法鉴定专业技术服务平台 司法部司法鉴定重点实验室，上海 200063； 2.中国药科大学 药学院，江苏 南京 210009
  • 收稿日期:2022-03-23 出版日期:2023-11-15 发布日期:2023-11-16
  • 作者简介:阳硕（1997—），女，硕士研究生，主要从事禁毒技术与毒物鉴定。E-mail: 1569793268@qq.com
  • 基金资助:
    中央科研院所公益项目（GY2021G-6）；上海市法医学重点实验室资助项目（21DZ2270800）；上海市司法鉴定专业技术服务平台资助项目。

Application of Pipette Tip Microextraction in Forensic Toxicological Analysis

YANG Shuo1,2， XIANG Jiahong1， LI Ziyi1,2， et al   

  1. 1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Shanghai 200063, China; 2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • Received:2022-03-23 Published:2023-11-15 Online:2023-11-16

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摘要： 在法医毒物分析中，高效的样品前处理方法至关重要，移液吸头微萃取是在传统固相萃取基础上发展形成的一类更高效、更环保的技术，可广泛应用于食品、环境、法医毒物相关分析。通过系统综述移液吸头微萃取技术在法医毒物尤其是生物检材中多种毒品检测分析中的应用，比较了不同微萃取方法、吸附剂、微萃取移液吸头类型的优缺点及应用范围，在法医毒物分析中展现出了较大的潜力，为相关毒物分析的前处理方法提供了新的解决方案和思路。

关键词: 毒物分析, 微固相萃取, 移液吸头微萃取, 精神活性物质

Abstract: Efficient sample pre-treatment methods are essential in forensic toxicological analysis. Pipette tip microextraction is a more efficient and environmentally-friendly technique developed from traditional solid-phase extraction. It can be widely used in food, environmental and forensic toxicological analysis. This paper systematically reviewed the applications of pipette tip microextraction techniques in the analysis of forensic toxic substances, especially illegal drugs in biological samples, and the advantages and disadvantages of different microextraction methods, sorbents, and tip types, as well as their application scopes were also compared. This technique shows great potential in forensic toxicology analysis, providing new solutions and ideas for the pre-treatment of forensic toxic substances analysis.

Key words: forensic toxicology, solid-phase microextraction, pipette-tip extraction, psychoactive substance

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