依托咪酯检测方法、毒性损害及滥用的研究进展

doi:10.3969/j.issn.1671-2072.2024.02.007

中国司法鉴定 ›› 2024 ›› Issue (2): 55-60.DOI: 10.3969/j.issn.1671-2072.2024.02.007

依托咪酯检测方法、毒性损害及滥用的研究进展

苏秦^1，2，杨成梁³，何美云³，赵枢泉^4，5，刘卫国^1，2，赵虎^4，5，刘超^{1，2，3，4}

1. 国家毒品实验室广东分中心，广东广州 510230；2. 广东省毒品实验技术中心，广东广州 510230；
3. 南方医科大学法医学院，广东广州 510515；4. 中山大学中山医学院法医学系，广东广州 510080；
5. 广东省法医学转化医学工程技术研究中心，广东广州 510080

收稿日期:2023-08-11 出版日期:2024-03-15 发布日期:2024-03-16
通讯作者: 赵虎（1963—），男，教授，博士，主要从事法医学研究与鉴定。E-mail：zhaohu3@mail.sysu.edu.cn 刘超（1963—），男，教授，博士，主要从事法医遗传学和法医病理学研究。E-mail：liuchaogzf@163.com
作者简介:苏秦（1990—），女，博士，主要从事法医遗传学和法医病理学研究。E-mail：qinsu1359@163.com
基金资助:
公安部技术研究计划项目（2022JSM02）。

Research Progress of Etomidate in Analyzing Methods, Toxic Damage and Abuse Situation

SU Qin^1,2，YANG Chengliang³, HE Meiyun³，ZHAO Shuquan^4,5, LIU Weiguo^1,2,ZHAO Hu^4,5, LIU Chao^1,2,3,4

1. National Anti-Drug Laboratory Guangdong Regional Center, Guangzhou 510230, China; 2. Anti-Drug Technology
Center of Guangdong Province, Guangzhou 510230, China; 3. School of Forensic Medicine, Southern Medical University,
Guangzhou 510515, China; 4. Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University,
Guangzhou 510080, China;5. Guangdong Province Translational Forensic Medicine Engineering Technology Research
Center, Guangzhou 510080, China

Received:2023-08-11 Published:2024-03-15 Online:2024-03-16

摘要/Abstract

摘要： 依托咪酯作为短效麻醉药在临床应用中广受认可，但在包括中国在内的一些国家却存在依托咪酯的滥用和误用问题，严重者则导致死亡。目前，中国已将依托咪酯列为第二类精神药品，具备毒品性质。非法滥用依托咪酯可能导致多器官系统的严重危害，包括内分泌、神经和心血管系统等。通过探讨依托咪酯滥用的毒性机制、毒性损害、代谢分布和检测方法，为其滥用监管和鉴定评价提供参考。

关键词: 依托咪酯, 色谱技术, 毒性损害, 滥用, 监管

Abstract: Although the clinical use of etomidate is widely recognized, there are issues of abuse and misuse of etomidate leading to fatalities, in some countries including China. Currently, China has classified etomidate as a second-class psychoactive drug with narcotic properties. Illicit use of etomidate can result in severe harm to multiple organ systems,including endocrine, nervous, and cardiovascular systems. By exploring the toxic mechanism, toxic damage, metabolic distribution, and analyzing methods of etomidate abuse, this paper provides a reference for the regulatory control and forensic evaluation of etomidate abuse.

Key words: etomidate, chromatographic technique, toxic damage, abuse, administration

中图分类号:

DF795.1

苏秦, 杨成梁, 何美云, 赵枢泉, 刘卫国, 赵虎, 刘超. 依托咪酯检测方法、毒性损害及滥用的研究进展[J]. 中国司法鉴定, 2024(2): 55-60.

SU Qin, YANG Chengliang, HE Meiyun, ZHAO Shuquan, LIU Weiguo, ZHAO Hu, LIU Chao. Research Progress of Etomidate in Analyzing Methods, Toxic Damage and Abuse Situation[J]. Chinese Journal of Forensic Sciences, 2024(2): 55-60.

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依托咪酯检测方法、毒性损害及滥用的研究进展

Research Progress of Etomidate in Analyzing Methods, Toxic Damage and Abuse Situation

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