主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

›› 2009 ›› Issue (03): 31-34.

• 论文 • 上一篇    下一篇

血小板同种抗原基因中9个单核苷酸多态性在广西地区壮族和汉族人群中的差异分析

焦伟;韩骁天;李瑶;秦岭;江斌;谢庆玲;林金盈;   

  1. 广西壮族自治区人民医院;复旦大学生命学院遗传所遗传工程国家重点实验室;上海博星法医物证司法鉴定所;

The Difference Analyses of 10 SNPs in HPA Gene Between Zhuang and Han in Guang Xi Area

JIAO Wei1, HAN Xiao-tian2, LI Yao2, QIN Ling1, JIANG Bin3, XIE Qing-ling1, LIN Jin-ying1(1.People's Hospital of Guangxi Zhuang Nationality Autonomous Region, Nanning 530021,China;2.State Key Laboratory of Genetics Engineering, Fudan University, Shanghai 2   

被引次数

1

摘要： 目的检测血小板同种抗原基因中9个单核苷酸多态性在广西地区壮族和汉族人群中的差异。方法利用基于单碱基延伸的单核苷酸多态性(SNP)分型芯片,对广西壮族地区99例壮族个体和107例汉族个体的染色体基因组上10个SNP位点进行了分型,其中9个位于6个血小板同种抗原基因中,1个位于基因间区。此外,结合Hapmap计划第二期公布的四个人群的SNP分型数据,分析这六个人群的遗传结构。结果广西原住汉族人在等位基因频率上未检测到与当地壮族有显著性的差异位点,但在基因型频率上,rs630014和rs9441951两位点是显著差异的。广西壮族人与广西汉族、北京汉族人及日本东京人的遗传结构相近,但与祖先来自欧洲西部和北部的犹他州居民以及尼日利亚伊巴丹的约鲁巴人有显著差异的遗传成分存在。结论壮汉两族由于历史上的多次基因交流可能导致其遗传信息在很大程度上是相近的。

关键词: 广西, 壮族, 汉族, 单核苷酸多态性, 遗传结构

Abstract: Objective To explore the difference of 10 SNPs in HPA gene between Zhuang and Han in Guang Xi area.Methods Ten SNPs were genotyped in 99 Zhuang individuals and 107 Han individuals.Nine of the ten SNPs located in the 6 human platelet alloantigen(HPA) coding genes, and the other one located in the inter-gene region.Analyses were conducted on the differences of allele frequencies and genotype frequencies between Han and Zhuang in Guang Xi area.Moreover, the genetic structure was analyzed for the two populations along with the four populations from Hapmap II data.Results There are no sig-nificant allele frequency differences of the 10 SNP loci between Zhuang and Han population in Guang Xi area, while the signif-icant difference of the genotype frequency are shown on rs630014 and rs9441951.The genetic structure of Guang Xi Zhuang, Guang Xi Han, Beijing Han and JPT are similar, while significant genetic structure difference is implied from CEU and YRI.Conclusion The frequent gene communication in history between Zhuang and Han in Guang Xi area could cause the genetic similarity in the two populations.

Key words: Guang Xi, Zhuang population, Han population, SNP, genetic structure