联合应用STR和SRY基因分型技术分析性分化异常者

›› 2009 ›› Issue (03): 83-85.

联合应用STR和SRY基因分型技术分析性分化异常者

林源;李成涛;

司法部司法鉴定科学技术研究所上海市法医学重点实验室;

Application of STR and SRY Techniques in Analyzing the Sex Reversal Syndrome Patient

LIN Yuan, LI Cheng-tao(Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, Shanghai 200063, China)

摘要/Abstract

摘要： 目的对Amelogenin分型结果为"X,X"的一名"男孩"进行性别确认。方法采用STR检测和SRY基因检测技术进行分析。结果孩子STR、X-STR的检验结果符合女性性别特征,SRY基因检测结果为阴性。结论应用STR、X-STR检测和SRY基因检测技术可以确证"男孩"Amelogenin基因座结果为"X,X",推断其患有"46,XX"男性性反转综合症。

关键词: 性分化异常, X-STR检测, SRY

Abstract: Objective To confirm a boy's gender character whose genotype of Amelogenin locus was"X,X".Methods Samples of the boy and his father were analyzed by PCR at both SRY gene and STR loci on autosome and Y,X chromosome.Results The boy's gender was confirmed as"X,X"by the detection results of Amelogenin, Y-STRs and X-STRs.Conclusion The boy suffered from"46, XX"sex reversal syndrome.

Key words: sex reversal syndrome, X-STR technique, SRY gene

林源;李成涛;. 联合应用STR和SRY基因分型技术分析性分化异常者[J]. , 2009(03): 83-85.

LIN Yuan;LI Cheng-tao(Shanghai Key Laboratory of Forensic Medicine;Institute of Forensic Science;Ministry of Justice;Shanghai 000;China). Application of STR and SRY Techniques in Analyzing the Sex Reversal Syndrome Patient[J]. , 2009(03): 83-85.