主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

中国司法鉴定 ›› 2020 ›› Issue (6): 17-27.DOI: 10.3969/j.issn.1671-2072.2020.06.003

• 鉴定综述 • 上一篇    下一篇

苯乙胺类新精神活性物质的研究进展

周莉英1，2，陈航1，向平1，乔正1，刘万卉2，卓悦1，岳琳娜1，施妍1   

  1. 1.司法鉴定科学研究院 上海法医学重点实验室 上海市司法鉴定专业技术服务平台 司法部司法鉴定重点实验室，上海200063； 2.烟台大学，山东 烟台264005
  • 收稿日期:2020-03-04 出版日期:2020-12-25 发布日期:2020-12-25
  • 通讯作者: 施妍，E-mail：shiy@ssfjd.cn
  • 作者简介:周莉英(1994—)，女，硕士研究生，从事法医毒物分析研究。
  • 基金资助:
    国家自然科学基金(81971789)；上海市科技攻关项目(19DZ1200600)；中央级科研院所公益项目 (GY2020 Z-2)；上海市法医学重点实验室项目 (17DZ2273200)；上海市司法鉴定专业技术服务平台资助项目(19DZ2292700)

Research Progress of New Psychoactive Substances of Phenethylamines

ZHOU Liying1,2， CHEN Hang1，XIANG Ping1， QIAO Zheng1， LIU Wanhui2，ZHUO Yue1， YUE Linna1, SHI Yan1   

  1. 1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Shanghai 200063, China; 2. School of Pharmacy, Yantai University, Yantai 264005, China
  • Received:2020-03-04 Published:2020-12-25 Online:2020-12-25
  • Contact: SHI Yan，E-mail：shiy@ssfjd.cn

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摘要： 苯乙胺类新精神活性物质是一类具有致幻和兴奋双重精神作用的化合物，以苯乙胺为母核，通过化学结构修饰合成苯乙胺类衍生物以规避法律的管控，其药理作用与传统毒品相似，甚至毒性更强。滥用苯乙胺类物质后，会出现恶心、呕吐、心动过速、高血压、呼吸抑制以及幻觉等症状，甚至发生严重肢体缺血、肝、肾功能衰竭并导致死亡，严重影响到人类的身心健康和公共安全。苯乙胺类新精神活性物质滥用引起了国际社会的高度关注，对其药理毒理及分析方法的研究成了法医毒物分析领域的研究热点。综述了苯乙胺类新精神活性物质的体内过程、样品前处理以及分析方法，以期为司法鉴定的实践提供依据。

关键词: 苯乙胺类新精神活性物质, 体内过程, 样品前处理

Abstract: New psychoactive substances of phenethylamines are a class of compounds with dual psychoactive effects of hallucinations and excitement. It uses phenethylamine as the mother nucleus, and through the chemical structure modification to synthesize phenethylamine derivatives to circumvent the laws and regulations of various countries. Its pharmacological effects are similar to traditional drugs, and even more toxic. Abuse of phenethylamines can cause symptoms such as nausea, vomiting, tachycardia, hypertension, respiratory depression, and hallucinations, and even severe limb ischemia, liver and kidney failure and death, which seriously affects human physical and mental health and public safety. New psychoactive substances of phenethylamines have drawn great attention from the international community, and the study of their pharmacological and toxicology and analysis methods has become a research hotspot in the field of forensic toxicology analysis. This article reviews the in vivo processes, sample preparation, and analysis methods of new psychoactive substances of phenethylamine, in order to provide a basis for the practice of forensic identification.

Key words: the new psychoactive substance of phenethylamines, in vivo process, sample preparation

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