主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

›› 2001 ›› Issue (03): 24-27.

• 论文 • 上一篇    下一篇

碱性成纤维细胞生长因子及其受体在脑损伤时的表达和应用

黄代新,吴梅筠,陈于波   

  1. 四川大学华西法医学院 ,四川大学华西法医学院 ,四川大学华西法医学院

The Expression and Application of bFGF and its Receptor following Brain Injuries

HUANG Dai-xin, WU Mei-jun, CHEN Yu-bo (Huaxi College of Forensic Medicine, Sichuan University)   

摘要： bFGF是一种广泛存在的多功能肽类生长因子,具有神经营养及促创伤修复功能。脑损伤可诱导bFGF及其特异性受体的表达,表明bFGF参与了CNS损伤后神经细胞的存活与损伤组织的修复过程,具有一定的治疗价值,同时其表达的时序性改变可作为一种客观指标用于法医学脑损伤时间的推断。

关键词: bFGF, 脑损伤, 神经营养作用, 创伤修复, 损伤时间推断

Abstract: Bfgfis a pluripotent peptide growth factor with neurotrophic effects and wound repairing functions. The study showed that gene expressions of bFGF and its receptor were induced by brain injuries, indicating that the bFGF contributes to the process of nerve cell survival and repair of damaged neural tissues after CNS injury. The patterns of bFGF and its receptor change level were quite regular, suggesting the potential for timing of injuries in the forensic aspect.

Key words: bFGF, brain injury, neurotrophic effect, repair of wounds, Timing of injury