Research Progress of Etomidate in Analyzing Methods, Toxic Damage and Abuse Situation

doi:10.3969/j.issn.1671-2072.2024.02.007

Abstract

Abstract: Although the clinical use of etomidate is widely recognized, there are issues of abuse and misuse of etomidate leading to fatalities, in some countries including China. Currently, China has classified etomidate as a second-class psychoactive drug with narcotic properties. Illicit use of etomidate can result in severe harm to multiple organ systems,including endocrine, nervous, and cardiovascular systems. By exploring the toxic mechanism, toxic damage, metabolic distribution, and analyzing methods of etomidate abuse, this paper provides a reference for the regulatory control and forensic evaluation of etomidate abuse.

Key words: etomidate, chromatographic technique, toxic damage, abuse, administration

摘要： 依托咪酯作为短效麻醉药在临床应用中广受认可，但在包括中国在内的一些国家却存在依托咪酯的滥用和误用问题，严重者则导致死亡。目前，中国已将依托咪酯列为第二类精神药品，具备毒品性质。非法滥用依托咪酯可能导致多器官系统的严重危害，包括内分泌、神经和心血管系统等。通过探讨依托咪酯滥用的毒性机制、毒性损害、代谢分布和检测方法，为其滥用监管和鉴定评价提供参考。

关键词: 依托咪酯, 色谱技术, 毒性损害, 滥用, 监管

CLC Number:

DF795.1

SU Qin, YANG Chengliang, HE Meiyun, ZHAO Shuquan, LIU Weiguo, ZHAO Hu, LIU Chao. Research Progress of Etomidate in Analyzing Methods, Toxic Damage and Abuse Situation[J]. Chinese Journal of Forensic Sciences, 2024(2): 55-60.

苏秦, 杨成梁, 何美云, 赵枢泉, 刘卫国, 赵虎, 刘超. 依托咪酯检测方法、毒性损害及滥用的研究进展[J]. 中国司法鉴定, 2024(2): 55-60.

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