Abstract: New psychoactive substances (NPS), as the third generation of drugs after traditional drugs and synthetic drugs, are being abused globally, and have become a prominent issue of priority concern for countries around the world. Novel synthetic opioids are one of the most potentially harmful substances and have been abused increasingly, posing a serious threat to human health and public safety. As one class of novel synthetic opioids, the problem of manufacturing, smuggling and abuse of Nitazenes are becoming more and more seriously all over the world. In this paper, the basic structure, abuse and control, pharmacological and toxicological properties, metabolism and detection methods of Nitazenes were reviewed. Moreover, the development of detection technology of Nitazenes were briefly prospected, in order to provide reference for further study of Nitazenes. 

Key words: new psychoactive substance (NPS), Nitazene, pharmacology and toxicology, metabolism, testing method

摘要： 新精神活性物质作为继传统毒品和合成毒品后的第三代毒品，在全球范围内的滥用愈发严重，已成为世界各国重点关注的突出问题。合成阿片类物质作为其中潜在危害最大的物质，其滥用种类不断增长，严重威胁人类健康和公共安全。尼秦类物质作为一类新型阿片类毒品，在全球范围内的制造、走私和滥用问题越来越突出。从尼秦类物质的基本结构、滥用和管制情况及其药理和毒理学性质、代谢情况、检测方法四个方面展开综述，对尼秦类物质的检测技术发展等方面进行简要展望，以期为尼秦类物质的深入研究提供思路。

关键词: 新精神活性物质, 尼秦类物质, 药理和毒理学, 代谢, 检验方法