SNP Typing Methodology and Its Application in Forensic Science

›› 2007 ›› Issue (06): 22-25.

SNP Typing Methodology and Its Application in Forensic Science

GUO Hong1,2,CHANG Jing-jing2,3,LI Li2(1.Medical School of Soochow University,Suzhou 215123,China;2.Institute of Forensic Science,Ministry of Justice,Shanghai 200063,China;3.Department of Forensic Medicine,Shanghai Medical College,Fudan University,Shanghai

SNP分型方法及在法医学等领域的应用

郭宏;畅晶晶;李莉;

苏州大学基础医学院,司法部司法鉴定科学技术研究所上海200063,司法部司法鉴定科学技术研究所,复旦大学上海医学院法医学系,上海200032,司法部司法鉴定科学技术研究所,,江苏苏州215006,上海200063,上海200063

Abstract

Abstract: Due to the haplotype map,SNPs show potential advantage not only on X-chromosome and autosomal but also on Y chromosome and mtDNA.In the forensic field,the interest of SNPs is continuously increasing because of the low mutation rates and suitability for analysis of degraded DNA.This report mainly describe the SNPs and X-chromosome SNPs characteristics,genotyping methods and its potential application in forensic medicine.

Key words: single nucleotide polymorphism(SNP), X-chromosome, SNP genotyping

摘要： 随着单倍型图的产生,SNP越来越受到关注。不仅仅在Y染色体和线粒体,常染色体和X染色体上的SNPs的应用潜能也将被发现。SNPs具有比较低的突变率和适合于降解DNA分析的特点,在法医学领域也受到关注。本文综合介绍了SNPs和X-SNPs的一般特性、分型方法及其在法医学的应用。

关键词: 单核苷酸多态性, X-染色体, SNP-分型

GUO Hong;CHANG Jing-jing;LI Li(.Medical School of Soochow University;Suzhou;China;.Institute of Forensic Science;Ministry of Justice;Shanghai 000;China;.Department of Forensic Medicine;Shanghai Medical College;Fudan University;Shanghai. SNP Typing Methodology and Its Application in Forensic Science[J]. , 2007(06): 22-25.

郭宏;畅晶晶;李莉;. SNP分型方法及在法医学等领域的应用[J]. , 2007(06): 22-25.