Abstract: Ethyl glucuronide(EtG) is a minor metabolite of ethanol, which only represents 0.02%-0.06% of the total ethanol intake.Following alcohol intake, EtG is reported to be detectable for an extended period of time after the complete elimination of ethanol from the body, so it can be used as a marker of alcohol abuse.Its detection in hair has become a hot subject of re-search in both clinical and forensic context for the purpose of alcohol abuse monitoring.The hair analysis of EtG requires more sensitive methods for its low concentration, which needs to be carried out by LC-MS/MS or GC-MS/MS.Special attentions should be paid in the decontamination procedures of hair sampling, washing and extracting to avoid a false positive result.Moreover, EtG concentration in hair may help to estimate the daily alcohol intake and can confirm abstinence, so it can be widely used in forensic science, treatment programs, workplaces, schools, troops as well as driving ability test to provide legal proof of drinking.

Key words: ethyl glucuronide(EtG), hair analysis, tandem mass-spectrum(MS/MS), alcohol abuse

摘要： 乙基葡萄糖醛酸酐(ethy lglucuronide,EtG)为乙醇的体内代谢物,摄入的乙醇大约0.02%～0.06%以EtG的形式排出,其消除时间较乙醇缓慢,即使当乙醇在体内完全消除后,EtG仍可作为酒精滥用的生物学标志。测定头发中的EtG可延长检测时限,获取饮酒史的信息,在法庭科学和临床医学领域已成为研究热点。头发中EtG的检测主要采用以串联质谱为主的高灵敏的分析方法,且注重头发采样、去污、水解、提取、分析等各环节的质量控制,避免出现假阳性结果。头发中EtG的研究结果可广泛应用于法庭科学、临床医学、征兵、招工、驾驶能力测试等领域。

关键词: EtG, 头发分析, 串联质谱, 酒精滥用