Application of Solid Phase Microextraction in Pharmaceutical Hair Analysis

Abstract

Abstract: Solid phase microextraction(SPME)can be used on line in combination with GC/MS and HPLC/MS,and the onestep integration of separating and analyzing provide potential application in hair analysis.The paper summarizes the research and application of SPME in hair analysis of abused drugs and their metabolites,such as amphetamine-type,methadone, cannabinoids,cocaine,lidocaine,and so on.

Key words: solid phase microextraction(SPME), hair analysis, amphetamines, cannabinoids, cocaine

摘要： 固相微萃取(SPME)可与GC/MS、HPLC/MS等在线联用,实现分离、分析一体化的特点为其在毛发药物分析中的应用提供了可能性和良好的应用前景。本文对SPME技术在毛发中滥用药物如苯丙胺类、美沙酮、大麻、可卡因、利多卡因等及其相应代谢产物的分析研究及应用进展做一综述。

关键词: 固相微萃取(SPME), 毛发分析, 苯丙胺类, 大麻, 可卡因

SUN Ying-ying;SHEN Min (.Department of forensic medicine;Institute of preclinical medicine and biological science;Soochow University;Soochow;China;.Shanghai Key Laboratory of Forensic Science;Institute of Forensic Science;Ministry of Justic. Application of Solid Phase Microextraction in Pharmaceutical Hair Analysis[J]. , 2010(03): 27-32+5.

孙英英;沈敏;. 固相微萃取技术在毛发药物分析中的应用[J]. , 2010(03): 27-32+5.

[1]	SHEN Min, YAN Hui, XU Duoqi, JI Jiaojiao. Frontier in Hair Analysis：Research Advances in Hair Microsampling Technology [J]. Chinese Journal of Forensic Sciences, 2023, 0(5): 22-30.
[2]	YANG Rongji, GAO Yujie, LIAO Caiyun, YANG Liu, LI Guojuan, XU Buyi. Simultaneous Determination of Seventeen Synthetic Cannabinoids in Electronic Tobacco Oil and Cut Tobacco by Gas Chromatography-Tandem Mass Spectrometry [J]. Chinese Journal of Forensic Sciences, 2023, 0(4): 45-51.
[3]	ZHENG Jiaming, WANG Xin, ZHAO Yunli, XIANG Ping. Research Progress of the Analysis of New Psychoactive Substances-Synthetic Cannabinoids in Hair [J]. Chinese Journal of Forensic Sciences, 2023, 126(1): 53-62.
[4]	WU Lina, XIAO Fu, LIN Jiaman, LI Tianle, XIANG Ping, SHI Yan, YUN Keming. Research Progress and Application of QSAR in New Psychoactive Substances [J]. Chinese Journal of Forensic Sciences, 2023, 126(1): 45-52.
[5]	YANG Huan, WANG Xin, YU Miao, XIANG Ping. Research Progress on Analytical Methods of Appetite Suppressants in Hair [J]. Chinese Journal of Forensic Sciences, 2021, 119(6): 43-52.
[6]	LIU Mengxi, XIANG Ping, YU Zhiguo, et al. Research Progress of Synthetic Cannabinoids New Psychoactive Substances [J]. Chinese Journal of Forensic Sciences, 2021, 117(4): 30-40.
[7]	ZHAO Hui, ZHUO Xian-yi, XIANG Ping, YAN Hui, SHEN Bao-hua. Analysis of Cannabinoids and The Main Metabolite in Human Hair by GC-MS/MS [J]. Chinese Journal of Forensic Sciences, 2012, 64(5): 71-74.
[8]	ZENG Li-bo;CHEN Lian-kang;HU Xiao-long;ZHANG Yu-rong;ZHANG Run-sheng(Shanghai Key Laboratory of Crime Scene Evidence;Insitute of Forensic Science;Shanghai Municipal Public Security Bureau;Shanghai 000;China). Preparation of Gold Colloidal Immunochromatographic Test Cassette for Detection of Cocaine and Benzoylecgonine [J]. , 2009, 0(06): 20-22+3.
[9]	SHI Yan;XIANG Ping;SHEN Bao-hua;SHEN Min(.Shanghai Key Laboratory of Forensic Medicine;Institute of Forensic Science;Ministry of Justice;Shanghai 000;China;.Shanghai Medical College of Fudan University;Shanghai 000;China). Review of Ethyl Glucuronide in Hair Analysis [J]. , 2009, 0(03): 24-30.
[10]	SUN Qi-ran;XIANG Ping;SHEN Min(Institute of Forensic Science;Ministry of Justice;Shanghai 000;China). Review of Hair Analysis after a Single Dose Administration [J]. , 2008, 0(03): 31-37.
[11]	ZUO Xian-yi;ZHAO Hui;XIANG Ping(. Institute of Forensic Science;Ministry of Justice;P.R.China;Shanghai 000;China;. Shanghai Medical College;Fudan University;Shanghai 000;China). Simultaneous Quantification of Canabinoids and the Major Metabolite THC-COOH in Urine Samples by LC/MS-MS [J]. , 2008, 0(01): 21-25.

Application of Solid Phase Microextraction in Pharmaceutical Hair Analysis

固相微萃取技术在毛发药物分析中的应用

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 11

Recommended Articles

Metrics