主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

中国司法鉴定 ›› 2022 ›› Issue (4): 20-32.DOI: 10.3969/j.issn.1671-2072.2022.04.003

• 鉴定综述 • 上一篇    下一篇

新型苯二氮䓬类策划药体内分析研究进展

陆佳玥1，2，严 慧2，沈 敏2   

  1. 1.华东政法大学 刑事法学院，上海 200042； 2.司法鉴定科学研究院 上海市法医学重点实验室 上海市司法鉴定专业技术服务平台 司法部司法鉴定重点实验室，上海 200063
  • 收稿日期:2022-03-28 出版日期:2022-07-15 发布日期:2022-08-15
  • 通讯作者: 沈敏（1955—），女，研究员，博士研究生导师，主要从事法医毒物鉴定研究和司法鉴定管理工作。E-mail:shenm@ssfjd.cn
  • 作者简介:陆佳玥（1999—），女，硕士研究生，主要从事法医毒物鉴定研究。E-mail:chiayuehlu@outlook.com
  • 基金资助:
    上海市法医学重点实验室资助项目（21DZ2270800）；上海市司法鉴定专业技术服务平台资助项目（19DZ2292700）。

Research Progress on the in Vivo Analytical Methods of Designer Benzodiazepines 

LU Jiayue1,2, YAN Hui2, SHEN Min2   

  1. 1. Criminal Justice College, East China University of Political Science and Law, Shanghai 200042, China; 2. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Shanghai 200063, China
  • Received:2022-03-28 Published:2022-07-15 Online:2022-08-15

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摘要： 新型苯二氮䓬类策划药是具有苯二氮䓬类药物的核心结构但不具有合法临床用途的一类新精神活性物质，近两年已成为全球新精神活性物质案件中检出率最高的化合物类型。此类化合物摄入后产生镇静、催眠、肌肉松弛、欣快等反应，通常作为处方药的替代品并用于药物滥用或“迷奸”“麻抢”等药物辅助犯罪，对公共安全产生严重威胁。因此，对于新型苯二氮䓬类策划药滥用的高效鉴定是当前司法鉴定领域的重要需求。通过对新型苯二氮䓬类策划药的构效关系、体内过程、样品处理、分析方法以及案例应用的研究进展进行综述，以期为司法鉴定实践提供参考。

关键词: 新型苯二氮?类策划药, 样品处理, 分析方法

Abstract: Designer benzodiazepines is a new class of psychoactive substances that have the core structure of benzodiazepines but do not have legal clinical use. In the past two years, they have become the most frequently detected type of compounds in new psychoactive substances (NPS) cases worldwide. These compounds produce sedative, hypnotic, muscle relaxation, euphoria and other effects after ingestion. They are often used as substitutes for prescription drugs in drug abuse or drug-assisted crimes such as "rape and mugging", posing a serious threat to public safety. Therefore, the efficient identification of new benzodiazepines is an important demand in the field of forensic toxicology. The research progress on the structure-activity relationship, in-vivo process, sample preparation, analytical methods and case applications of new benzodiazepine drugs is reviewed to provide reference for forensic practice.

Key words: designer benzodiazepines, sample preparation, analytical method

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