Research Progress on Analytical Methods for Dextromethorphan and Its Metabolites

doi:10.3969/j.issn.1671-2072.2026.01.003

Abstract

Abstract: The illegal abuse of dextromethorphan, a widely used antitussive drug in clinical practice, has increasingly become an international issue. Currently, China has listed dextromethorphan in its national catalog of Category II Psychotropic Drugs and implements control measures in accordance with standards for narcotics regulation. Based on relevant literature, this study summarizes the metabolic pathways, abuse hazards, and control status of dextromethorphan, with a focus on the extraction and detection methods for dextromethorphan and its metabolites. It analyzes and discusses the applicability of these methods across different matrices, their qualitative and quantitative detection performance, and their multidimensional application scenarios in forensic appraisal. This study aims to provide a reference for the detection, identification, and abuse monitoring of dextromethorphan in the field of forensic appraisal.

Key words: dextromethorphan, metabolite, abuse, analytical method

摘要： 右美沙芬作为临床常用镇咳药物，其非法滥用已逐渐成为国际性问题。目前，中国已将其列入第二类精神药品目录，按照毒品管制标准实施管控。结合相关文献报道，在概述右美沙芬代谢途径、滥用危害和管制情况的基础上，着重阐述了针对右美沙芬及其代谢物的提取方法和检测方法，分析和讨论了不同基质下的方法适用性、定性（量）检测效能和司法鉴定中的多维应用场景等，以期为司法鉴定领域中右美沙芬的检验鉴定和滥用监测提供参考。

关键词: 右美沙芬, 代谢物, 滥用, 分析方法

CLC Number:

DF795.1

WU Chenghao, WEI Dali, DENG Chunmeng, WANG Peixia, PAN Teng, ZHANG Zhen. Research Progress on Analytical Methods for Dextromethorphan and Its Metabolites[J]. Chinese Journal of Forensic Sciences, 2026(1): 21-31.

吴成豪, 韦达理, 邓春萌, 王培霞, 潘腾, 张祯. 右美沙芬及其代谢物分析检测方法研究进展[J]. 中国司法鉴定, 2026(1): 21-31.

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