主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
Chinese Journal of Forensic Sciences

Chinese Journal of Forensic Sciences ›› 2026 ›› Issue (5): 78-84.DOI: 10.3969/j.issn.1671-2072.2026.05.010

• Forensic Science • Previous Articles     Next Articles

Analysis of Phencyclidine-type New Psychoactive Substance 2-FXE in Illicit E-liquid

YANG Xiaoying1, QIAN Jiali1, WANG Rui1, ZHANG Runxuan1, ZHOU Xiao1, JING Hang2, MA Lixia2   

  1. 1. Key Laboratory of Drugs Analysis & Intelligent-Monitoring, National Narcotics Laboratory Shaanxi Regional Center （The Narcotics Control Technical Center of Shaanxi Provincial Public Security Department）; 2. College of Medicine & Forensics, Xi’an Jiaotong University
  • Published:2026-09-15 Online:2026-09-29

非法电子烟油中苯环利定类新精神活性物质2-FXE的分析

杨晓莹1，千佳丽1，王    蕊1，张闰璇1，周    潇1，井    航2，马丽霞2   

  1. 1. 国家毒品实验室陕西分中心（陕西省公安厅毒品技术中心）  陕西省毒品分析与毒情智慧监测研究重点实验室； 2.西安交通大学 法医学院

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Abstract: Objective This study established qualitative analytical methods for 2-Ethylamino-2- (2-fluorophenyl)cyclohexan-1-one (2-FXE) in e-liquid using gas chromatography-mass spectrometry (GC-MS) and high resolution-liquid chromatography-mass spectrometry (HR-LC-MS). Corresponding quantitative analytical methods were established using high performance liquid chromatography (HPLC) and gas chromatography (GC). Methods The seized e-liquid sample was extracted with methanol and subjected to qualitative analysis using HR-LC-MS and GC-MS. Furthermore, the content of the target substance in e-liquid was quantitatively analyzed using HPLC and GC. Results The mass fragment information of HR-LC-MS indicated that the unknown substance may be 2-FXE, an analog of Fluoroketamine. Combined with the retention time and the relative ion abundance ratio of the reference standard analyzed by GC-MS, the unknown additive was determined to be 2-FXE. At the same time, the quantitative results of HPLC and GC showed that the illegal addition of 2-FXE in e-liquid was 8.22% and 8.35%, respectively. The relative deviation between the two results was less than 5%. Conclusion This approach can meet the qualitative and quantitative analysis requirements of 2-FXE in e-liquid, and also provides a reference method for the analysis of other similar phencyclidine-type new psychoactive substances.

Key words: GC-MS, HR-LC-MS, HPLC, phencyclidine-type substance, 2-FXE, e-liquid

摘要： 目的 建立电子烟油中苯环利定类物质2-乙氨基-2-（2-氟苯基）环己酮[2-（Ethylamino）-2-（2-fluorophenyl）cyclohexan-1-one，2-FXE]的气相色谱-质谱法（gas chromatography-mass spectrometry，GC-MS）和高分辨液相色谱-质谱法（high resolution-liquid chromatography-mass spectrometry，HR-LC-MS）的定性分析方法，同时采用高效液相色谱法（high performance liquid chromatography，HPLC）和气相色谱法（gas chromatography，GC）对其进行定量分析。方法 缴获的电子烟油经甲醇提取后，采用HR-LC-MS和GC-MS进行定性分析，同时采用HPLC和GC对电子烟油中2-FXE的含量进行定量分析。结果 该方法利用HR-LC-MS的质谱碎片信息推断未知物可能为氟胺酮的类似物2-FXE，结合GC-MS对照标准品的保留时间和离子丰度比确定未知添加物为2-FXE，实现了对电子烟油中2-FXE的定性识别。同时，HPLC和GC的定量结果显示电子烟油中2-FXE的非法添加量分别为8.22%、8.35%，两者的定量结果相对偏差小于5%。结论 该方法能够满足电子烟油中2-FXE的定性、定量分析要求，也为其他类似的苯环利定类新精神活性物质的鉴定分析提供参考。

关键词: GC-MS, HR-LC-MS, HPLC, 苯环利定类物质, 2-FXE, 电子烟油

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