Identification of Metonitazene, a Nitazene New Psychoactive Substance in E-liquids

doi:10.3969/j.issn.1671-2072.2025.03.007

Chinese Journal of Forensic Sciences ›› 2025 ›› Issue (3): 51-58.DOI: 10.3969/j.issn.1671-2072.2025.03.007

• Forensic Science • Previous Articles Next Articles

Identification of Metonitazene, a Nitazene New Psychoactive Substance in E-liquids

YANG Qiao¹, HU Rui², WU Bo³, CAO Yu¹, TANG Boyi², ZHANG Zhonghui¹, SU Mengxiang²

1. Division of Narcotic Control, Nanjing Public Security Bureau, Nanjing 210042, China;
2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
3. Department of Criminal Investigation, Nanjing Public Security Bureau, Nanjing 210001, China

Received:2024-04-10 Published:2025-05-15 Online:2025-05-16

电子烟油中尼秦类新精神活性物质美托尼秦的鉴定分析

杨乔¹，胡瑞²，吴波³，曹煜¹，唐泊伊²，张忠辉¹，苏梦翔²

1. 南京市公安局禁毒支队，江苏南京 210042； 2. 中国药科大学药学院，江苏南京 210009；
3.南京市公安局刑事侦查局，江苏南京 210001

作者简介:杨乔（1987—），男，工程师，硕士，主要从事毒品分析研究。E-mail:451062477@qq.com

Abstract

Abstract: Objective To identify metonitazene in e-liquids seized from drug cases. Methods Methods of gas chromatography-mass spectrometry (GC-MS) and ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) were established to identify metonitazene. The compound was also analyzed by ultraviolet-visible absorption spectrum (UV-Vis), Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (NMR) methods. Results The GC-MS result showed that there was an unknown compound at the retention time of 15.295 min, and its characteristic ions were m/z 86 (base peak), 121, 58, and 382, which was identified as metonitazene by comparing with the standard substance. The structural information of the target acquired by UV-Vis, FTIR and NMR were supplemented. Conclusion The comprehensive use of various techniques to analyze metonitazene in e-liquid samples can provide structural information to confirm the detection of this kind of new psychoactive substances.

Key words: metonitazene, gas chromatography-mass spectrometry (GC-MS), ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS), ultraviolet-visible absorption spectrum (UV-Vis), Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), e-liquid

摘要： 目的对毒品案件缴获的电子烟油中的美托尼秦进行定性检验。方法采用气相色谱-质谱法（gas chromatography-mass spectrometry，GC-MS）和超高效液相色谱-高分辨质谱法（ultra-high performance liquid chromatography-high resolution mass spectrometry，UHPLC-HRMS）对美托尼秦进行鉴定，同时通过紫外可见吸收光谱法（ultraviolet-visible absorption spectrum，UV-Vis）、傅里叶变换红外光谱法（Fourier transform infrared spectroscopy，FTIR）和核磁共振波谱法（nuclear magnetic resonance spectroscopy，NMR）分析美托尼秦。结果 GC-MS结果显示，保留时间15.295 min处有一未知化合物，其特征离子为m/z 86（基峰）、121、58、382，后经标准品比对确证该未知化合物为美托尼秦，并提供美托尼秦UV-Vis、FTIR和NMR相关结构数据。结论综合运用多种技术对电子烟油检材中的美托尼秦进行分析，可为该类新精神活性物质的检验鉴定提供参考。

关键词: 美托尼秦, 气相色谱-质谱法, 超高效液相色谱-高分辨质谱法, 紫外可见吸收光谱法, 傅里叶变换红外光谱法, 核磁共振波谱法, 电子烟油

CLC Number:

DF795.1

YANG Qiao, HU Rui, WU Bo, CAO Yu, TANG Boyi, ZHANG Zhonghui, SU Mengxiang. Identification of Metonitazene, a Nitazene New Psychoactive Substance in E-liquids[J]. Chinese Journal of Forensic Sciences, 2025(3): 51-58.

杨乔, 胡瑞, 吴波, 曹煜, 唐泊伊, 张忠辉, 苏梦翔. 电子烟油中尼秦类新精神活性物质美托尼秦的鉴定分析[J]. 中国司法鉴定, 2025(3): 51-58.

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Identification of Metonitazene, a Nitazene New Psychoactive Substance in E-liquids

电子烟油中尼秦类新精神活性物质美托尼秦的鉴定分析

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