Abstract: Objective To assess the power of PowerPlex21 system in paternity testing. Methods 1704 paternity testing cases were studied with PowerPlex21 system, and the exclusion power and mutation rate of the PowerPlex21 system were analysed. Results The cumulated chance of exclusion and the cumulated discriminating power were both more than 0.999 999 999 999 999 999 999 999 999 999. 265 out of 1704 cases were excluded, which often showed 8-10 exclusion loci. Gene mutation was observed in 44 cases. Conclusion PowerPlex21 system was highly effective for paternity testing．

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摘要： 目的 评估PowerPlex21系统20个STR基因座在亲子鉴定中的检验能力。方法 用PowerPlex21系统检测1 704例亲子鉴定，评估该系统在亲子鉴定中的排除能力和突变率。结果 采用PowerPlex21系统，累积非父排除率和累积个体识别力均大于0.999 999 999 999 999 999 999 999 999 999。1704例亲子鉴定中有265例排除亲子关系，最常见为8～10个基因座排除；44例表现为1个STR基因座突变。结论 PowerPlex21系统用于亲子鉴定是高效的。

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