主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
Chinese Journal of Forensic Sciences

›› 2010 ›› Issue (01): 30-32.

• 论文 • Previous Articles     Next Articles

Poor Metabolizing of Ethanol and Acetaldehyde with alcohol-related Traffic Accident

LI Li1,LI Cheng-tao1,ZHAO Shu-min1,ZHANG Su-hua1,2,XIANG Ping1 (1. Shanghai Key Laboratory of Forensic Medicine,Institute of Forensic Science,Ministry of Justice,Shanghai 200063,China; 2. Medical School of Soochow University,Suzhou 215123,China)   

乙醇、乙醛慢代谢与酒后驾车肇事

李莉;李成涛;赵书民;张素华;向平;   

  1. 司法部司法鉴定科学技术研究所上海市法医学重点实验室;苏州大学基础医学院;

Cited

3

Abstract: Alcohol dehydrogenase (ADH),acetaldehyde dehydrogenase (ALDH) and cytochrome P450 2E1 (CYP2E1) with gene polymorphism play important roles in alcohol metabolism in vivo. Individuals with distinct genotypes are different in alcohol tolerance and show unequal behavioral responses after drinking. Poor metabolism of alcohol and acetaldehyde in blood will low individual's capability of judgment and may lead to traffic accidents. This article reviews the relationship of gene polymorphism of ADH,ALDH and CYP2E1 and the metabolism capability of alcohol and acetaldehyde.

Key words: ethano, acetaldehyde, metabolism, traffic accident

摘要： 在体内乙醇代谢过程中起重要作用的酶有乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)和细胞色素P4502E1酶(CYP2E1),它们均具有基因多态性,不同基因型个体对乙醇的耐受性存在差别,表现为酒后的行为反应能力不同。司机若为慢代谢型,乙醇、乙醛代谢速率低下,即使少量饮酒,酒后开车也可造成交通肇事。通过对ADH、ALDH和CYP2E1基因多态性与乙醇、乙醛代谢能力的关系进行综述。

关键词: 乙醇, 乙醛, 代谢, 交通事故