主管：中华人民共和国司法部
主办：司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N
中国司法鉴定

中国司法鉴定 ›› 2024 ›› Issue (5): 68-71.DOI: 10.3969/j.issn.1671-2072.2024.05.009

• 鉴定科学 • 上一篇    下一篇

浅析三带型基因座同一认定似然比的计算策略

海璇隽1，黄建春2   

  1. 1. 龙岩市公安局刑事侦查支队，福建 龙岩 364000；2. 福建省公安厅刑事技术总队，福建 福州 350001
  • 收稿日期:2023-08-29 出版日期:2024-09-15 发布日期:2024-11-28
  • 作者简介:海璇隽（1987—），女，警务技术副高级任职资格，硕士，主要从事法医DNA检验鉴定。E-mail：623884806@qq.com

A Preliminary Analysis of the Calculation Strategy for the Likelihood Ratio of Identity Identification of Tri-allelic Pattern Loci

HAI Xuanjun1, HUANG Jianchun2   

  1. 1. Criminal Investigation Detachment, Longyan Public Security Bureau, Longyan 364000, China; 
    2. Criminal Technology Corps, Fujian Provincial Public Security Department, Fuzhou 350001, China
  • Received:2023-08-29 Published:2024-09-15 Online:2024-11-28

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摘要： 目的 探讨短串联重复序列（short tandem repeat，STR）三带型基因座同一认定似然比（likelihood ratio，LR）的不同计算策略。方法 通过忽略三带型基因座、基于人群中不同类型的观测值、基于三带型基因座形成机制推导公式三个模型，对三带型基因座似然比进行计算。结果 得到三个模型六种策略的LR计算方法，并分析其保守性与局限性。结论 根据三体综合征发生机制推导的三带型基因座LR计算公式，可得到较为准确且可用于司法鉴定的LR值。

关键词: 法医遗传学, 短串联重复序列, 三带型, 似然比

Abstract: Objective To explore different calculation strategies for the likelihood ratio (LR) identity identification of tri-allelic pattern short tandem repeat (STR) loci. Methods Calculated the LR of tri-allelic pattern loci by ignoring the tri-allelic pattern loci, based on observations values in population, and based on the formula derivated from the mechanism of tri-allelic pattern loci. Results The LR calculation methods for three models and six strategies were obtained, and their conservatism and limitations were analyzed. Conclusion The LR calculation formula for tri-allelic pattern loci can be derived based on the mechanism of trisomy syndrome, enabling the acquisition of more accurate LR values applicable in forensic appraisal.

Key words: forensic genetics, short tandem repeat (STR), tri-allelic pattern, likelihood ratio (LR)

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