Abstract: Objective To establish a method for the simultaneous determination of 17 synthetic cannabinoids based on gas chromatography tandem triple quadrupole mass spectrometry （GC-MS/MS）. Methods The synthetic cannabinoids were separated on an HP-5MS capillary column （30 m×0.25 mm, 0.25 μm） and detected by mass spectrometry in multiple reaction monitoring （MRM） mode. Quantification was performed using external calibration curves. Results The calibration curves of 17 synthetic cannabinoids were linear in the range of 20-1 000 ng/mL with correlation coefficients greater than 0.999. The limits of detection and limits of quantitation  were in the range of 4-6 ng/mL and 12-20 ng/mL, respectively. The intra-day precision deviation was less than 5.5 % and the inter-day precision deviation was less than 8.5 %. The recovery rates ranged from 83.2 % to 113.2 % for the solution of electronic cigarette oil, and from 90.2 % to 116.8 % for the tobacco exact. Conclusion The established method is simple, rapid, highly sensitive and accurate for the simultaneous determination of a variety of synthetic cannabinoids.

Key words: gas chromatography-tandem mass spectrometry （GC-MS/MS）, synthetic cannabinoids, multiple reaction monitoring （MRM）

摘要： 目的 建立一种同时测定电子烟油和烟丝中17种合成大麻素的气相色谱-串联三重四极杆质谱法。方法 选用HP-5MS毛细管柱（30 m × 0.25 mm， 0.25 μm）分离，采用多反应监测模式测定，以外标法定量。结果 17种合成大麻素在20~1 000 ng/mL范围内线性关系良好，相关系数均大于0.999，检出限为4~6 ng/mL，定量限为12~20 ng/mL，日内精密度小于5.5 %，日间精密度小于8.5 %，在烟油基质中的回收率为83.2 %~113.2 %，在烟丝提取液基质中的回收率为90.2 %~116.8 %。结论 该方法简便快捷、检出限低、准确度高，可用于涉及多种合成大麻素样本的检测。

关键词: 气相色谱-串联质谱法, 合成大麻素, 多反应监测模式