Abstract: The dried matrix spot （DMS） micro-sampling technique is a form of sample collection and storage, which is formed by the collection of trace biological liquid （such as blood, urine and saliva） on the card and the drying. Compared with the traditional sampling method, DMS micro-sampling technique has obvious advantages: small sample size, simple sample processing, convenient storage and transportation, it has been applied in the field of epidemiological investigation, toxicological monitoring, pharmacokinetics and toxicokinetics. In order to promote the development and application of DMS micro-sampling technology in forensic toxicology and the progress of identification technology, this paper reviewed the methods of sample collection, storage stability, sample processing and analysis of DMS.

Key words: dried matrix spot; mMicro-sampling technique; forensic toxicology; review

摘要： 干生物基质点（Dried Matrix Spot，DMS）微样技术是通过将微量生物液体（如血液、尿液和唾液等）收集于卡纸上并干燥后形成的样本采集和储存形式。干生物基质点微样技术较传统的采样方法有明显的优势：取样量小，样品处理简单，储存运输方便，目前已应用于流行病学调查、毒药物监测、药代动力学研究和毒代动力学研究等领域。通过对干生物基质的样品采集、储存稳定性、样品处理和分析方法等方面进行综述，以推动DMS微样技术在法医毒物学领域的拓展应用及鉴定技术的进步。

关键词: 干生物基质点；微样技术；法医毒物学；综述