Chinese Journal of Forensic Sciences ›› 2025 ›› Issue (2): 20-30.DOI: 10.3969/j.issn.1671-2072.2025.02.003
• Forensic Review • Previous Articles Next Articles
YAN Hui1, LU Jiayue1,2, SHEN Min1
Received:
2024-06-12
Published:
2025-03-15
Online:
2025-03-25
严 慧1,陆佳玥1,2, 沈 敏1
作者简介:
严慧(1984—),女,研究员,博士,主要从事法医毒物学研究。E-mail:yanh501@163.com
基金资助:
CLC Number:
YAN Hui, LU Jiayue, SHEN Min. Analysis of International Research Hotspots in Forensic Toxicology Based on Bibliometrics[J]. Chinese Journal of Forensic Sciences, 2025(2): 20-30.
严 慧, 陆佳玥, 沈 敏. 基于文献计量学的法医毒物学国际研究热点分析[J]. 中国司法鉴定, 2025(2): 20-30.
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.chsfjd.cn/EN/10.3969/j.issn.1671-2072.2025.02.003
[ 1 ] JONES A W. Crème de la crème in forensic science and legal medicine[J].International Journal of Legal Medicine,2005,119(2):59-65. [ 2 ] FERRARA S D,BAJANOWSKI T,CECCHI R,et al. Bio-medicolegal scientific research in Europe:A comprehensive bibliometric overview[J]. International Journal of Legal Medicine,2011,125(3):393-402. [ 3 ] 严慧,史格非,沈敏. 基于文献计量学指标的法医毒物学研究状况分析[J]. 中国司法鉴定,2019(4):29-37. [ 4 ] ARIA M,CUCCURULLO C. Bibliometrix:An R-tool for comprehensive science mapping analysis[J]. Journal of Informetrics,2017,11(4):959-975. [ 5 ] CHEN C,IBEKWE‐SANJUAN F,HOU J. The structure and dynamics of cocitation clusters:A multiple-perspective cocitation analysis[J]. Journal of the American Society for Information Science and Technology,2010,61(7):1386-1409. [ 6 ] BOSCOLO-BERTO R,VIEL G,CECCHI R,et al. Journals publishing bio-medicolegal research in Europe[J].International Journal of Legal Medicine,2012,126(1):129-137. [ 7 ] VIEL G,BOSCOLO-BERTO R,CECCHI R,et al. Bio-medicolegal scientific research in Europe. A country-based analysis[J]. International Journal of Legal Medicine,2011,125(5):717-725. [ 8 ] BADE R,WHITE J M,CHEN J,et al. International snapshot of new psychoactive substance use:Case study of eight countries over the 2019/2020 new year period[J]. Water Research,2021,193:116891. [ 9 ] COLLINS M. Some new psychoactive substances:Precursor chemicals and synthesis‐driven end‐products[J]. Drug Testing and Analysis,2011,3(7/8):404-416. [10] DIAO X,SCHEIDWEILER K B,WOHLFARTH A,et al. Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201:Metabolism of FUBIMINA in human hepatocytes[J]. Forensic Toxicology,2016,34(2):256-267. [11] MAAS A,SYDOW K,MADEA B,et al. Separation of ortho,meta and para isomers of methylmethcathinone (MMC) and methylethcathinone (MEC) using LC-ESI-MS/MS:Application to forensic serum samples[J]. Journal of Chromatography B,2017,1051:118-125. [12] MAHER S,ELLIOTT S P,GEORGE S. The analytical challenges of cyclopropylfentanyl and crotonylfentanyl:An approach for toxicological analysis[J]. Drug Testing and Analysis,2018,10(9):1483-1487. [13] MOSTOWTT T,MCCORD B. Surface enhanced Raman spectroscopy (SERS) as a method for the toxicological analysis of synthetic cannabinoids[J].Talanta,2017,164:396-402. [14] KUŚ P,KUSZ J,KSIĄŻEK M,et al. Spectroscopic characterization and crystal structures of two cathinone derivatives:N-ethyl-2-amino-1-phenylpropan-1-one (ethcathinone) hydrochloride and N-ethyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-CEC) hydrochloride[J]. Forensic Toxicology,2017,35(1):114-124. [15] SPÁLOVSKÁ D,MAŘÍKOVÁ T,KOHOUT M,et al. Methylone and pentylone:Structural analysis of new psychoactive substances[J]. Forensic Toxicology,2019,37(2):366-377. [16] CASTANETO M S,WOHLFARTH A,PANG S,et al. Identification of AB-FUBINACA metabolites in human hepatocytes and urine using high-resolution mass spectrometry[J]. Forensic Toxicology,2015,33(2):295-310. [17] SWORTWOOD M J,ELLEFSEN K N,WOHLFARTH A,et al. First metabolic profile of PV8,a novel synthetic cathinone,in human hepatocytes and urine by high-resolution mass spectrometry[J]. Analytical and Bioanalytical Chemistry,2016,408(18):4845-4856. [18] ÅSTRAND A,TÖRESKOG A,WATANABE S,et al. Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl,cyclobutyl fentanyl,cyclopentyl fentanyl,cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS[J]. Archives of Toxicology,2019,93(1):95-106. [19] MCKENZIE C,SUTCLIFFE O B,READ K D,et al. Chemical synthesis,characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users[J]. Forensic Toxicology,2018,36(2):359-374. [20] WATANABE S,VIKINGSSON S,ÅSTRAND A,et al. Metabolism of the benzodiazepines norflurazepam,flurazepam,fludiazepam and cinolazepam by human hepatocytes using high-resolution mass spectrometry and distinguishing their intake in authentic urine samples[J]. Forensic Toxicology,2020,38(1):79-94. [21] MINAKATA K,YAMAGISHI I,HASEGAWA K,et al. In vitro and in vivo human metabolism of a synthetic cannabinoid EAM-2201 detected by LC-quadrupole-ion trap-MS/MS and high-resolution LC-Orbitrap-MS/MS[J]. Forensic Toxicology,2019,37(2):432-442. [22] WATANABE S,IWAI T,MATSUSHITA R,et al. Comparison between human liver microsomes and the fungus Cunninghamella elegans for biotransformation of the synthetic cannabinoid JWH-424 having a bromo-naphthyl moiety analysed by high-resolution mass spectrometry[J]. Forensic Toxicology,2022,40(2):278-288. [23] WATANABE S,KUZHIUMPARAMBIL U,WINIARSKI Z, et al. Biotransformation of synthetic cannabinoids JWH-018,JWH-073 and AM2201 by Cunninghamella elegans[J]. Forensic Science International,2016,261:33-42. [24] LEONG H S,WATANABE S,KUZHIUMPARAMBIL U,et al. Monitoring metabolism of synthetic cannabinoid 4F-MDMB-BINACA via high-resolution mass spectrometry assessed in cultured hepatoma cell line,fungus,liver microsomes and confirmed using urine samples[J]. Forensic Toxicology,2021,39(1):198-212. [25] DAHM P,THOMAS A,ROTHSCHILD M A,et al. Phase I-metabolism studies of the synthetic cannabinoids PX-1 and PX-2 using three different in vitro models[J]. Forensic Toxicology,2022,40(2):244-262. [26] WAGMANN L,FRANKENFELD F,PARK Y M,et al. How to study the metabolism of new psychoactive substances for the purpose of toxicological screenings—a follow-up study comparing pooled human liver S9,HepaRG cells,and zebrafish larvae[J]. Frontiers in Chemistry,2020,8:539. [27] RICHTER L H J,BECK A,FLOCKERZI V,et al. Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay[J]. Toxicology Letters,2019,301:79-89. [28] RICHTER L H J,FLOCKERZI V,MAURER H H,et al. Pooled human liver preparations,HepaRG,or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA,MDBD,butylone,MDPPP,MDPV,MDPB,5-MAPB,and 5-API as examples[J]. Journal of Pharmaceutical and Biomedical Analysis,2017,143:32-42. [29] NIELSEN L,LINNET K,OLSEN L,et al. Prediction of cytochrome P450 mediated metabolism of designer drugs[J]. Current Topics in Medicinal Chemistry,2014,14(11):1365-1373. [30] DIAO X,WOHLFARTH A,PANG S,et al. High-resolution mass spectrometry for characterizing the metabolism of synthetic cannabinoid THJ-018 and its 5-fluoro analog THJ-2201 after incubation in human hepatocytes[J]. Clinical Chemistry,2016,62(1):157-169. [31] STRANO-ROSSI S,ANZILLOTTI L,DRAGONI S,et al. Metabolism of JWH-015,JWH-098,JWH-251,and JWH-307 in silico and in vitro:A pilot study for the detection of unknown synthetic cannabinoids metabolites[J]. Analytical and Bioanalytical Chemistry,2014,406(15):3621-3636. [32] MONTESANO C,VANNUTELLI G,FANTI F,et al. Identification of MT-45 metabolites:in silico prediction,in vitro incubation with rat hepatocytes and in vivo confirmation[J]. Journal of Analytical Toxicology,2017,41(8):688-697. [33] ELLEFSEN K N,WOHLFARTH A,SWORTWOOD M J,et al. 4-Methoxy-α-PVP:In silico prediction,metabolic stability,and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry[J]. Forensic Toxicology,2016,34(1):61-75. [34] BRUNETTI P,LO FARO A F,DI TRANA A,et al. β′-Phenylfentanyl metabolism in primary human hepatocyte incubations:identification of potential biomarkers of exposure in clinical and forensic toxicology[J]. Journal of Analytical Toxicology,2023,46(9):e207-e217. [35] KINTZ P. Value of the concept of minimal detectable dosage in human hair[J]. Forensic Science International,2012,218(1-3):28-30. [36] KUWAYAMA K,MIYAGUCHI H,KANAMORI T,et al. Micro-segmental hair analysis:Detailed procedures and applications in forensic toxicology[J]. Forensic Toxicology,2022,40(2):215-233. [37] KUWAYAMA K,MIYAGUCHI H,IWATA Y T,et al. Three-step drug extraction from a single sub-millimeter segment of hair and nail to determine the exact day of drug intake[J]. Analytica Chimica Acta,2016,948:40-47. [38] KUWAYAMA K,MIYAGUCHI H,KANAMORI T,et al. Distribution profiles of diphenhydramine and lidocaine in scalp,axillary,and pubic hairs measured by micro-segmental hair analysis:Good indicator for discrimination between administration and external contamination of the drugs[J]. Forensic Toxicology,2022,40(1):64-74. [39] KUWAYAMA K,MIYAGUCHI H,IWATA Y T,et al. Strong evidence of drug-facilitated crimes by hair analysis using LC-MS/MS after micro-segmentation[J]. Forensic Toxicology,2019,37(2):480-487. [40] XU D,JI J,XIANG P,et al. Two DFSA cases involving midazolam clarified by the micro-segmental hair analyses[J]. Forensic Toxicology,2022,40(2):374-382. [41] LIN H,ZENG X,WANG Q,et al. Identification and imaging of indole-3-carboxamide cannabinoids in hair using matrix-assisted laser-desorption/ionization mass spectrometry[J]. Forensic Toxicology,2020,38(1):216-226. [42] WANG H,WANG Y,WANG G,et al. Matrix-assisted laser-desorption/ionization mass spectrometric imaging of olanzapine in a single hair using esculetin as a matrix[J]. Journal of Pharmaceutical and Biomedical Analysis,2017,141:123-131. [43] NAKANISHI T,NIRASAWA T,TAKUBO T. Quantitative mass barcode-like image of nicotine in single longitudinally sliced hair sections from long-term smokers by matrix-assisted laser desorption time-of-flight mass spectrometry imaging[J]. Journal of Analytical Toxicology,2014,38(6):349-353. [44] SHIMA N,SASAKI K,KAMATA T,et al. Single-hair analysis of zolpidem on the supposition of its single administration in drug-facilitated crimes[J]. Forensic Toxicology,2015,33(1):122-130. [45] FLINDERS B,CUYPERS E,ZEIJLEMAKER H,et al. Preparation of longitudinal sections of hair samples for the analysis of cocaine by MALDI-MS/MS and TOF-SIMS imaging[J]. Drug Testing and Analysis,2015,7(10):859-865. [46] KINTZ P. 2014 Consensus for the use of alcohol markers in hair for assessment of both abstinence and chronic excessive alcohol consumption[J]. Forensic Science International,2015,249:A1-A2. [47] TRIOLO V,SPANÒ M,BUSCEMI R,et al. EtG quantification in hair and different reference cut-offs in relation to various pathologies:a scoping review[J]. Toxics,2022,10(11):682. [48] BINZ T M,BAUMGARTNER M R,KRAEMER T. The influence of cleansing shampoos on ethyl glucuronide concentration in hair analyzed with an optimized and validated LC-MS/MS method[J]. Forensic Science International,2014,244:20-24. [49] PETZEL‐WITT S,POGODA W,WUNDER C,et al. Influence of bleaching and coloring on ethyl glucuronide content in human hair[J]. Drug Testing and Analysis,2018,10(1):177-183. [50] LUGINBÜHL M,NUSSBAUMER S,WEINMANN W. Decrease of ethyl glucuronide concentrations in hair after exposure to chlorinated swimming pool water[J]. Drug Testing and Analysis,2018,10(4):689-693. [51] MIOLO G,STOCCHERO G,VOGLIARDI S,et al. A study on photostability of ethyl glucuronide in hair irradiated under artificial sunlight[J]. Journal of Analytical Toxicology,2020,44(1):58-64. [52] TSANACLIS L,BAGLEY K,BEVAN S,et al. The effect of prolonged storage time on the stability of fatty acid ethyl esters in hair samples[J]. Journal of Analytical Toxicology,2020,44(8):829-833. [53] EISENBEISS L,BINZ T M,BAUMGARTNER M R,et al. A possible new oxidation marker for hair adulteration:Detection of PTeCA (1H‐pyrrole‐2,3,4,5‐tetracarboxylic acid) in bleached hair[J]. Drug Testing and Analysis,2020,12(2):230-238. [54] MUELLER A,JUNGEN H,IWERSEN-BERGMANN S,et al. Determination of ethyl glucuronide in human hair samples:A multivariate analysis of the impact of extraction conditions on quantitative results[J]. Forensic Science International,2017,271:43-48. [55] KINTZ P,AMELINE A,RAUL J. Human hair tests to document drug environmental contamination:Application in a family law case involving N,N‐dimethyltryptamine[J]. Drug Testing and Analysis,2021,13(2):447-450. [56] FAVRETTO D,VOGLIARDI S,TUCCI M,et al. Occupational exposure to ketamine detected by hair analysis:A retrospective and prospective toxicological study[J].Forensic Science International,2016,265:193-199. [57] JACQUES A L B,SANTOS M K,GORZIZA R P,et al. Dried matrix spots:An evolving trend in the toxicological field[J].Forensic Science,Medicine and Pathology,2022,18(1):86-102. [58] AMBACH L,HERNÁNDEZ REDONDO A,KÖNIG S,et al. Rapid and simple LC‐MS/MS screening of 64 novel psychoactive substances using dried blood spots[J]. Drug Testing and Analysis,2014,6(4):367-375. [59] DA CUNHA K F,EBERLIN M N,COSTA J L. Development and validation of a sensitive LC-MS/MS method to analyze NBOMes in dried blood spots:Evaluation of long-term stability[J]. Forensic Toxicology,2018,36(1):113-121. [60] DA CUNHA K F,EBERLIN M N,COSTA J L. Long-term stability of synthetic cathinones in dried blood spots and whole blood samples:A comparative study[J].Forensic Toxicology,2018,36(2):424-434. [61] KUMMER N,INGELS A-S,WILLE S M R,et al. Quantification of phosphatidylethanol 16∶0/18∶1,18∶1/18∶1,and 16∶0/16∶0 in venous blood and venous and capillary dried blood spots from patients in alcohol withdrawal and control volunteers[J].Analytical and Bioanalytical Chemistry,2016,408(3):825-838. [62] VELGHE S,DELAHAYE L,STOVE C P. Is the hematocrit still an issue in quantitative dried blood spot analysis?[J]. Journal of Pharmaceutical and Biomedical Analysis,2019,163:188-196. [63] Clinical and Laboratory Standards Institute. NBS01| Dried blood spot specimen collection for newborn screening[EB/OL].[2024-03-27].https://clsi.org/standards/products/newborn-screening/documents/nbs01/. [64] With dried blood spot analysis,anti-doping science is pushing the boundaries at Beijing 2022 and beyond[EB/OL]. [2024-03-27].https://www.wada-ama.org/en/news/dried-blood-spot-analysis-anti-doping-science-pushing-boundaries-beijing-2022-and-beyond. [65] LUGINBÜHL M,STÖTH F,SCHRÖCK A,et al. Quantitative determination of phosphatidylethanol in dried blood spots for monitoring alcohol abstinence[J]. Nature Protocols,2021,16(1):283-308. [66] MAURER H H. What is the future of (ultra) high performance liquid chromatography coupled to low and high resolution mass spectrometry for toxicological drug screening?[J]. Journal of Chromatography A,2013,1292:19-24. [67] GONCALVES R,PELLETIER R,COUETTE A,et al. Suitability of high-resolution mass spectrometry in analytical toxicology:Focus on drugs of abuse[J].Toxicologie Analytique et Clinique,2022,34(1):29-41. [68] HOPFGARTNER G,TONOLI D,VARESIO E. High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices[J]. Analytical and Bioanalytical Chemistry,2012,402(8):2587-2596. [69] WHITMAN J D,LYNCH K L. Optimization and comparison of information-dependent acquisition (IDA) to sequential window acquisition of all theoretical fragment ion spectra (SWATH) for high-resolution mass spectrometry in clinical toxicology[J]. Clinical Chemistry,2019,65(7):862-870. [70] ÁLVAREZ-RUIZ R,PICÓ Y. Sequential window acquisition of all theoretical fragments versus information dependent acquisition for suspected-screening of pharmaceuticals in sediments and mussels by ultra-high pressure liquid chromatography-quadrupole time-of-flight-mass spectrometry[J]. Journal of Chromatography A,2019,1595:81-90. [71] ROEMMELT A T,STEUER A E,POETZSCH M,et al. Liquid chromatography,in combination with a quadrupole time-of-flight instrument (LC QTOF),with sequential window acquisition of all theoretical fragment-ion spectra (SWATH) acquisition:Systematic studies on its use for screenings in clinical and forensic toxicology and comparison with information-dependent acquisition (IDA)[J]. Analytical Chemistry,2014,86(23):11742-11749. [72] BOXLER M I,SCHNEIDER T D,KRAEMER T,et al. Analytical considerations for (un)‐targeted metabolomic studies with special focus on forensic applications[J]. Drug Testing and Analysis,2019,11(5):678-696. [73] LE DARÉ B,ALLARD S,COUETTE A,et al. Comparison of illicit drug seizures products of natural origin using a molecular networking approach[J]. International Journal of Toxicology,2022,41(2):108-114. [74] STREUN G L,ELMIGER M P,DOBAY A,et al. A machine learning approach for handling big data produced by high resolution mass spectrometry after data independent acquisition of small molecules—Proof of concept study using an artificial neural network for sample classification[J]. Drug Testing and Analysis,2020,12(6):836-845. [75] STREUN G L,STEUER A E,POETZSCH S N,et al. Towards a new qualitative screening assay for synthetic cannabinoids using metabolomics and machine learning[J]. Clinical Chemistry,2022,68(6):848-855. |
[1] | QIAN Xiaoyu, XIANG Ping, YAN Hui. Application of Metabolomics in the Investigation of New Psychoactive Substances [J]. Chinese Journal of Forensic Sciences, 2025, 0(2): 31-39. |
[2] | SHEN Ruidi, QIAN Zhenhua. Research Progress of Nitazenes New Psychoactive Substances and Their Testing Methods [J]. Chinese Journal of Forensic Sciences, 2024, 0(4): 21-28. |
[3] | WANG Xin, CHEN Hang, XIANG Ping. Fighting Against Drugs ——Overview of the 60th Annual Meeting of TIAFT in 2023 [J]. Chinese Journal of Forensic Sciences, 2024, 0(1): 36-41. |
[4] | XU Feng, XUAN Yu, ZHUO Xiaocong, FU Lixiang, CHEN Feng, WANG Binjie, GUO Difei, YU Pengfei. Simultaneous Determination of 12 Antidepressants in Human Blood by UHPLC-MS/MS [J]. Chinese Journal of Forensic Sciences, 2024, 0(1): 53-60. |
[5] | YANG Shuo, XIANG Jiahong, LI Ziyi, XU Linhao, SHI Yan, LIU Wei. Application of Pipette Tip Microextraction in Forensic Toxicological Analysis [J]. Chinese Journal of Forensic Sciences, 2023, 0(6): 40-47. |
[6] | HUANG Yumin, PAN Tong, LIU Qingbo, SUN Mao, SUN Pengfei, WU Yuanming. Determination of Phoxim in Milk Powder by Gas Chromatography-Mass Spectrometry [J]. Chinese Journal of Forensic Sciences, 2023, 0(6): 75-79. |
[7] | SHEN Min, YAN Hui, XU Duoqi, JI Jiaojiao. Frontier in Hair Analysis:Research Advances in Hair Microsampling Technology [J]. Chinese Journal of Forensic Sciences, 2023, 0(5): 22-30. |
[8] | WU Lina, XIAO Fu, LIN Jiaman, LI Tianle, XIANG Ping, SHI Yan, YUN Keming. Research Progress and Application of QSAR in New Psychoactive Substances [J]. Chinese Journal of Forensic Sciences, 2023, 0(1): 45-52. |
[9] | ZHENG Jiaming, WANG Xin, ZHAO Yunli, XIANG Ping. Research Progress of the Analysis of New Psychoactive Substances-Synthetic Cannabinoids in Hair [J]. Chinese Journal of Forensic Sciences, 2023, 0(1): 53-62. |
[10] | LU Jiayue, YAN Hui, CHEN Hang, SHEN Min. Current Status of Research on New Psychoactive Substances in Forensic Toxicology in China — Based on Bibliometric Analysis [J]. Chinese Journal of Forensic Sciences, 2022, 0(6): 37-47. |
[11] | REN Hang, ZHAO Yunli, YUAN Shuai, XIANG Ping, SHEN Baohua. Discovering Global Trends in Illicit Drugs by Wastewater-Based Epidemiology [J]. Chinese Journal of Forensic Sciences, 2022, 0(5): 22-38. |
[12] | HUANG Chunhua, XIANG Wei, WANG Siqi, WANG Yifan, LOU Didong, . Research Progress on Toxicity and Toxicology of Traditional Chinese Medicine Containing Aristolochic Acids [J]. Chinese Journal of Forensic Sciences, 2022, 0(4): 33-41. |
[13] | ZHAI Wenya, XIANG Ping, QIAO Zheng, DANG Yonghui, SHI Yan. Research Progress on New Psychoactive Substances of Phenethylamines and Their Metabolism [J]. Chinese Journal of Forensic Sciences, 2022, 0(3): 24-35. |
[14] |
YANG Huan, WANG Xin, YU Miao, XIANG Ping.
Research Progress on Analytical Methods of Appetite Suppressants in Hair [J]. Chinese Journal of Forensic Sciences, 2021, 0(6): 43-52. |
[15] |
JIANG Shijia, YAN Hui, SHEN Min.
Application of Paper Spray-Mass Spectrometry in Forensic Toxicology [J]. Chinese Journal of Forensic Sciences, 2021, 0(5): 65-74. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||