关键词: 法医病理学, 丙泊酚, 中毒, 司法鉴定

Abstract: Propofol is one of the most commonly used anesthetic sedative drugs in clinical practice. It has the advantages of rapid onset of action, rapid and complete patient resuscitation, and no accumulation after continuous infusion. However, recent studies have shown that propofol may be potentially addictive, and it is associated with allergy, respiratory depression, cardiovascular disease and other adverse reactions. As the use of propofol has become more widespread, the number of deaths due to improper use of propofol has increasing. When forensic pathologists are faced with such cases, they should fully understand the related knowledge of the mechanism and adverse effects of propofol, forensic pathological changes caused by death, and propofol toxic lethality. Through searching a large number of literatures about propofol, a systematic review of the pharmacological effects, adverse effects, forensic pathological changes and toxic lethality of propofol was carried out in this paper for the reference of peers.

Key words: forensic pathology, propofol, poisoning, forensic appraisal