主管:中华人民共和国司法部
主办:司法鉴定科学研究院
ISSN 1671-2072  CN 31-1863/N

中国司法鉴定 ›› 2021 ›› Issue (1): 29-38.DOI: 10.3969/j.issn.1671-2072.2021.01.004

• 鉴定综述 • 上一篇    下一篇

干生物基质点微样技术及其在法医毒物学中的应用

郭彩霞1,2,严慧1,刘伟1,沈敏1   

  1. 1.司法鉴定科学研究院 上海市法医学重点实验室 上海市司法鉴定专业技术服务平台 司法部司法鉴定重点实验室,上海 200063; 2.中国药科大学药学院,江苏 南京210009
  • 收稿日期:2020-11-05 出版日期:2021-02-25 发布日期:2021-02-25
  • 通讯作者: 沈敏,E-mail:shenm@ssfjd.cn
  • 作者简介:郭彩霞(1996—),女,硕士研究生,主要从事法医毒物分析研究。
  • 基金资助:
    国家重点研发计划“科技冬奥”专项(2020YFF0304505);上海市法医学重点实验室资助项目(17DZ2273200);上海市司法鉴定专业技术服务平台资助项目(19DZ2292700)

The Dried Matrix Spot Micro-sampling Technique and its Application in Forensic Toxicology

GUO Caixia1,2, YAN Hui1, LIU Wei1, SHEN Min1   

  1. 1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Senice Platform, Key Lab of Forensic Science, Ministry of Justice, Academy of Forensic Science, Shanghai 200063, China; 2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • Received:2020-11-05 Published:2021-02-25 Online:2021-02-25
  • Contact: SHEN Min,E-mail:shenm@ssfjd.cn

摘要: 干生物基质点(Dried Matrix Spot,DMS)微样技术是通过将微量生物液体(如血液、尿液和唾液等)收集于卡纸上并干燥后形成的样本采集和储存形式。干生物基质点微样技术较传统的采样方法有明显的优势:取样量小,样品处理简单,储存运输方便,目前已应用于流行病学调查、毒药物监测、药代动力学研究和毒代动力学研究等领域。通过对干生物基质的样品采集、储存稳定性、样品处理和分析方法等方面进行综述,以推动DMS微样技术在法医毒物学领域的拓展应用及鉴定技术的进步。

关键词: 干生物基质点;微样技术;法医毒物学;综述

Abstract: The dried matrix spot (DMS) micro-sampling technique is a form of sample collection and storage, which is formed by the collection of trace biological liquid (such as blood, urine and saliva) on the card and the drying. Compared with the traditional sampling method, DMS micro-sampling technique has obvious advantages: small sample size, simple sample processing, convenient storage and transportation, it has been applied in the field of epidemiological investigation, toxicological monitoring, pharmacokinetics and toxicokinetics. In order to promote the development and application of DMS micro-sampling technology in forensic toxicology and the progress of identification technology, this paper reviewed the methods of sample collection, storage stability, sample processing and analysis of DMS.

Key words: dried matrix spot; mMicro-sampling technique; forensic toxicology; review

中图分类号: